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Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men.

Abstract:
We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet-cancer associations.
Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6600946

Authors


Gunnell, D More by this author
Oliver, SE More by this author
Peters, TJ More by this author
Donovan, JL More by this author
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Journal:
British journal of cancer
Volume:
88
Issue:
11
Pages:
1682-1686
Publication date:
2003-06-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:8710ede9-3477-46a1-a7d2-c3866da9c8eb
Source identifiers:
120725
Local pid:
pubs:120725

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