The matrix protein hnRNP U is required for chromosomal localization of Xist RNA.

Journal article

In XX female mammals, one of the two X chromosomes is epigenetically inactivated to equalize gene expression with XY males. The formation of the inactive X chromosome (Xi) is regulated by an X-linked long noncoding RNA Xist, which accumulates on the entire length of the chromosome in cis and induces heterochromatin formation. However, the mechanism by which Xist RNA "paints" the Xi has long remained elusive. Here, we show that a matrix protein hnRNP U/SP120/SAF-A is required for the accumulat...

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Authors: Hasegawa, Y; Brockdorff, N; Kawano, S; Tsutui, K; Tsutui, K

• Publication status: Published
• Journal: Developmental cell
• Volume: 19
• Issue: 3
• Pages: 469-476
• Publication date: 2010-09-01
• DOI: 10.1016/j.devcel.2010.08.006
• EISSN: 1878-1551
• ISSN: 1534-5807
• Language: English
• Keywords: Histones; Cell Proliferation; RNA-Binding Proteins; RNA, Small Interfering; X Chromosome Inactivation; Female; In Situ Hybridization; Embryo, Mammalian; Immunoenzyme Techniques; Blotting, Western; Neuroblastoma; RNA, Long Noncoding; Fibroblasts; Mice; RNA, Messenger; Male; Reverse Transcriptase Polymerase Chain Reaction; Heterogeneous-Nuclear Ribonucleoprotein U; RNA, Untranslated; Heterochromatin; Animals