Journal article
Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.
- Abstract:
-
Thymic epithelial cell differentiation, growth and function depend on the expression of the transcription factor Foxn1; however, its target genes have never been physically identified. Using static and inducible genetic model systems and chromatin studies, we developed a genome-wide map of direct Foxn1 target genes for postnatal thymic epithelia and defined the Foxn1 binding motif. We determined the function of Foxn1 in these cells and found that, in addition to the transcriptional control of...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
Actions
Access Document
- Publisher copy:
- 10.1038/ni.3537
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature immunology Journal website
- Publication date:
- 2016-08-22
- Acceptance date:
- 2016-07-19
- DOI:
- EISSN:
-
1529-2916
- ISSN:
-
1529-2908
- Pubs id:
-
pubs:640494
- URN:
-
uri:870a1ebf-5f47-4a55-9a5b-e836270cfb0f
- UUID:
-
uuid:870a1ebf-5f47-4a55-9a5b-e836270cfb0f
- Local pid:
- pubs:640494
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- © 2016 Nature America, Inc. All rights reserved.
- Copyright date:
- 2016
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Nature Publishing Group at: 10.1038/ni.3537
If you are the owner of this record, you can report an update to it here: Report update to this record