- Abstract:
-
Thymic epithelial cell differentiation, growth and function depend on the expression of the transcription factor Foxn1; however, its target genes have never been physically identified. Using static and inducible genetic model systems and chromatin studies, we developed a genome-wide map of direct Foxn1 target genes for postnatal thymic epithelia and defined the Foxn1 binding motif. We determined the function of Foxn1 in these cells and found that, in addition to the transcriptional control of...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Publisher copy:
- 10.1038/ni.3537
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature immunology Journal website
- Publication date:
- 2016-08-22
- Acceptance date:
- 2016-07-19
- DOI:
- EISSN:
-
1529-2916
- ISSN:
-
1529-2908
- Pubs id:
-
pubs:640494
- URN:
-
uri:870a1ebf-5f47-4a55-9a5b-e836270cfb0f
- UUID:
-
uuid:870a1ebf-5f47-4a55-9a5b-e836270cfb0f
- Local pid:
- pubs:640494
- Language:
- English
- Keywords:
- Copyright holder:
- © 2016 Nature America, Inc. All rights reserved.
- Copyright date:
- 2016
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Nature Publishing Group at: 10.1038/ni.3537
Journal article
Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.
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