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Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.

Abstract:

Thymic epithelial cell differentiation, growth and function depend on the expression of the transcription factor Foxn1; however, its target genes have never been physically identified. Using static and inducible genetic model systems and chromatin studies, we developed a genome-wide map of direct Foxn1 target genes for postnatal thymic epithelia and defined the Foxn1 binding motif. We determined the function of Foxn1 in these cells and found that, in addition to the transcriptional control of...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/ni.3537

Authors


Žuklys, Saulius More by this author
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
Zhanybekova, Saule More by this author
Govani, Fatima More by this author
Keller, Marcel More by this author
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Funding agency for:
Handel, Adam
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Funding agency for:
Ponting, Chris P.
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Funding agency for:
Ponting, Chris P.
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Funding agency for:
Holländer, Georg A.
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Funding agency for:
Holländer, Georg A.
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature immunology Journal website
Publication date:
2016-08-22
Acceptance date:
2016-07-19
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Pubs id:
pubs:640494
URN:
uri:870a1ebf-5f47-4a55-9a5b-e836270cfb0f
UUID:
uuid:870a1ebf-5f47-4a55-9a5b-e836270cfb0f
Local pid:
pubs:640494
Language:
English
Keywords:

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