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Assessment of acute bowel toxicity from chemoradiation for bladder cancer using an in vivo gastrointestinal crypt assay and in vitro organoid system

Abstract:

Radiotherapy combined with a radiosensitiser is effective treatment in muscle-invasive bladder cancer, but can result in severe bowel toxicity. The classical crypt assay can be used to assess gut toxicity in vivo following whole abdominal radiation. The recent development of delivering focussed radiation to bladder and surrounding bowel by small animal radiation research platform (SARRP) requires a modification of the classical crypt assay to identify the irradiated lengths of intestine. We a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.urolonc.2017.06.024

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Groselj, B More by this author
Scudamore, CL More by this author
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Publisher:
Elsevier Publisher's website
Volume:
35
Issue:
10
Pages:
614-615
Publication date:
2017-10-16
Acceptance date:
2017-10-06
DOI:
EISSN:
1873-2496
ISSN:
1078-1439
Pubs id:
pubs:809729
URN:
uri:87068bc8-59df-49c2-b53d-066a6e9edf85
UUID:
uuid:87068bc8-59df-49c2-b53d-066a6e9edf85
Local pid:
pubs:809729

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