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A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais.

Abstract:

BACKGROUND: CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to developing an effective HIV-1 vaccine, and it is likely that regional-specific vaccine strains will be required to overcome the diversity of the different HIV-1 clades distributed world-wide. Unfortunately, little is known about the CD8+ T cell responses against CRF01_AE, which is responsible for the majority of infections in Southeast As...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0023603

Authors


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National Institutes of Health More from this funder
National Center for Genetic Engineering and Biotechnology (BIOTEC) Thailand More from this funder
Commission of Higher Education (CHE) in Thailand More from this funder
Royal Golden Jubilee Ph.D. Program More from this funder
Higher Education Research Promotion and National Research University Project of Thailand More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
6
Issue:
8
Pages:
Article: e23603
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:8701bae1-5865-44fd-ab41-4780625f48ab
Source identifiers:
175163
Local pid:
pubs:175163

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