Type 1 11beta -hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets.

Journal article

Metabolic transformation of glucocorticoid hormones constitutes a determinant of their cell-specific effects. The most important reaction for this class of steroids is the reversible C11 keto/beta-hydroxyl conversion between receptor-binding 11beta-OH steroids and the nonbinding 11-oxo compounds, carried out by 11beta-hydroxysteroid dehydrogenases (11beta-HSDs). In this study, we determined the role of glucocorticoid conversion by 11beta-HSD in pancreatic islets and its function in the regula...

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Authors: Davani, B; Khan, A; Hult, M; Mårtensson, E; Okret, S

• Journal: Journal of biological chemistry
• Volume: 275
• Issue: 45
• Pages: 34841-34844
• Publication date: 2000-11-01
• DOI: 10.1074/jbc.c000600200
• EISSN: 1083-351X
• ISSN: 0021-9258
• Language: English
• Keywords: Dose-Response Relationship, Drug; Animals; Glucose; Mice, Mutant Strains; Reverse Transcriptase Polymerase Chain Reaction; Carbenoxolone; Transcription, Genetic; Ligands; Mice; Genes, Reporter; Hydroxysteroid Dehydrogenases; Isoenzymes; Insulin; Humans; Diabetes Mellitus, Type 2; Tissue Distribution; RNA, Messenger; Kinetics; Pancreas; Corticosterone; 11-beta-Hydroxysteroid Dehydrogenases; Islets of Langerhans; Anti-Ulcer Agents; Mice, Knockout; Glucocorticoids