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Type 1 11beta -hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets.

Abstract:

Metabolic transformation of glucocorticoid hormones constitutes a determinant of their cell-specific effects. The most important reaction for this class of steroids is the reversible C11 keto/beta-hydroxyl conversion between receptor-binding 11beta-OH steroids and the nonbinding 11-oxo compounds, carried out by 11beta-hydroxysteroid dehydrogenases (11beta-HSDs). In this study, we determined the role of glucocorticoid conversion by 11beta-HSD in pancreatic islets and its function in the regula...

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Publisher copy:
10.1074/jbc.c000600200

Authors


Mårtensson, E More by this author
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Journal:
The Journal of biological chemistry
Volume:
275
Issue:
45
Pages:
34841-34844
Publication date:
2000-11-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:87013ca0-c80a-4315-945b-ce33dc06531f
Source identifiers:
108556
Local pid:
pubs:108556

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