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Pancreatic islet amyloid and elevated proinsulin secretion in familial maturity-onset diabetes.

Abstract:

Quantitative morphometry of immunostained pancreatic islet cells in a surgical specimen from a maturity-onset diabetic (MOD) patient (A) has been combined with a study of beta-cell secretion in him and his MOD son (B). The morphometry showed intra-islet amyloid deposits in 24% of islet sections which is a similar distribution to that found in 7 other MODs, (median 24%, range 0-95%). The distribution of islet cells in the pancreas from A was similar to the 7 MODs and 9 age matched non-diabetic...

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Publication status:
Published

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Authors


Matthews, DR More by this author
Naylor, BA More by this author
Hosker, JP More by this author
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Journal:
Diabetes research (Edinburgh, Scotland)
Volume:
4
Issue:
2
Pages:
51-55
Publication date:
1987-02-05
ISSN:
0265-5985
URN:
uuid:86fbccca-8191-41f2-a9b6-2fb36b0223fd
Source identifiers:
72985
Local pid:
pubs:72985

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