Journal article icon

Journal article

Natural history of GATA1 mutations in Down syndrome.

Abstract:

Acquired mutations in megakaryocyte transcription factor GATA1 have recently been reported in Down syndrome (DS), transient myeloproliferative disorder (TMD), and acute megakaryoblastic leukemia (AMKL). To provide novel insight into GATA1 mutations in DS, genomic DNA was assayed from 12 AMKL and 4 TMD cases (including neonatal, prediagnosis samples in 4 of 16), neonatal blood spots from 21 DS children without clinically evident TMD or AMKL, and 62 non-DS cord blood samples, using techniques n...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1182/blood-2003-10-3383

Authors


Sternberg, A More by this author
Expand authors...
Journal:
Blood
Volume:
103
Issue:
7
Pages:
2480-2489
Publication date:
2004-04-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:86f02d33-0030-46e1-a36c-c0ccc2140dca
Source identifiers:
32570
Local pid:
pubs:32570

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP