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Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

Abstract:

OBJECTIVE: Connective tissue growth factor (CTGF; CCN2) is overexpressed in systemic sclerosis (SSc) and has been hypothesized to be a key mediator of the pulmonary fibrosis frequently observed in this disease. CTGF is induced by transforming growth factor beta (TGFbeta) and is a mediator of some profibrotic effects of TGFbeta in vitro. This study was undertaken to investigate the role of CTGF in enhanced expression of type I collagen in bleomycin-induced lung fibrosis, and to delineate the ...

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Publication status:
Published

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Publisher copy:
10.1002/art.24620

Authors


Ponticos, M More by this author
Holmes, AM More by this author
Shi-wen, X More by this author
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Journal:
Arthritis and rheumatism
Volume:
60
Issue:
7
Pages:
2142-2155
Publication date:
2009-07-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:86e92d37-1202-4756-a093-06afc160e5f3
Source identifiers:
223528
Local pid:
pubs:223528

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