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Journal article

CD8+ T cells contribute to the development of transplant arteriosclerosis despite CD154 blockade.

Abstract:

BACKGROUND: The CD40-CD154 receptor-ligand pair plays a critical role in allograft rejection by mediating the activation of endothelial cells, antigen-presenting cells, and T cells. Blockade of this interaction prevents acute allograft rejection and leads to prolonged allograft survival in numerous experimental models, but in most cases indefinite graft survival is not achieved due to evolving transplant arteriosclerosis. In this study, we have used a model of transplant arteriosclerosis to i...

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Publication status:
Published

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Journal:
Transplantation
Volume:
69
Issue:
12
Pages:
2609-2612
Publication date:
2000-06-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:86e73d96-fe67-40a8-85da-cf1ca85a98e9
Source identifiers:
135919
Local pid:
pubs:135919

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