- Abstract:
-
CC3 (TIP30) is a protein with pro-apoptotic and anti-metastatic properties. The tumor suppressor effect of CC3 has been suggested to result from inhibition of nuclear transport by binding to importin betas or by regulating transcription through interaction in a complex with co-activator independent of AF-2 function (CIA) and the c-myc gene. Previous biochemical studies indicated that CC3 has protein kinase activity, and a structural similarity to cAMP-dependent protein kinase catalytic subuni...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m501113200
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 280
- Issue:
- 18
- Pages:
- 18229-18236
- Publication date:
- 2005-05-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:86e39f32-aac0-48d3-b200-47fc28ecd4ce
- Source identifiers:
-
72626
- Local pid:
- pubs:72626
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor.
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