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Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor.

Abstract:

CC3 (TIP30) is a protein with pro-apoptotic and anti-metastatic properties. The tumor suppressor effect of CC3 has been suggested to result from inhibition of nuclear transport by binding to importin betas or by regulating transcription through interaction in a complex with co-activator independent of AF-2 function (CIA) and the c-myc gene. Previous biochemical studies indicated that CC3 has protein kinase activity, and a structural similarity to cAMP-dependent protein kinase catalytic subuni...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m501113200

Authors


El Omari, K More by this author
Nichols, CE More by this author
Stammers, DK More by this author
Journal:
The Journal of biological chemistry
Volume:
280
Issue:
18
Pages:
18229-18236
Publication date:
2005-05-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:86e39f32-aac0-48d3-b200-47fc28ecd4ce
Source identifiers:
72626
Local pid:
pubs:72626

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