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Journal article

Defining requirements for collagenase cleavage in collagen type III using a bacterial collagen system.

Abstract:

Degradation of fibrillar collagens is important in many physiological and pathological events. These collagens are resistant to most proteases due to the tightly packed triple-helical structure, but are readily cleaved at a specific site by collagenases, selected members of the matrix metalloproteinases (MMPs). To investigate the structural requirements for collagenolysis, varying numbers of GXY triplets from human type III collagen around the collagenase cleavage site were inserted between t...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m112.348979

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of biological chemistry
Volume:
287
Issue:
27
Pages:
22988-22997
Publication date:
2012-06-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
329087

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