A review of RCTs in four medical journals to assess the use of imputation to overcome missing data in quality of life outcomes.
BACKGROUND: Randomised controlled trials (RCTs) are perceived as the gold-standard method for evaluating healthcare interventions, and increasingly include quality of life (QoL) measures. The observed results are susceptible to bias if a substantial proportion of outcome data are missing. The review aimed to determine whether imputation was used to deal with missing QoL outcomes. METHODS: A random selection of 285 RCTs published during 2005/6 in the British Medical Journal, Lancet, New Englan...Expand abstract
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