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Cervical human immunodeficiency virus type 1 shedding is associated with genital beta-chemokine secretion.

Abstract:

Forty human immunodeficiency virus type 1 (HIV-1)-infected women participated in a cross-sectional study of possible correlations between chemokine receptor (CCR5 and/or CCR2B) genotype, HIV-1 RNA and DNA load, and beta-chemokine levels (RANTES, MIP-1alpha, MIP-1beta) in blood and cervix. HIV-1 nucleic acid and beta-chemokines were found in all patient blood samples and in more than half of the cervical samples regardless of CCR5 or CCR2B genotype. High beta-chemokine concentrations were in g...

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Publisher copy:
10.1086/314433

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Journal:
The Journal of infectious diseases
Volume:
178
Issue:
5
Pages:
1334-1342
Publication date:
1998-11-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:86bc0f51-d346-4cdc-8fce-a4f157af20dd
Source identifiers:
68058
Local pid:
pubs:68058

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