Systemic regulation of vascular NAD(P)H oxidase activity and nox isoform expression in human arteries and veins.

Journal article

OBJECTIVE: Impaired endothelial function, characterized by nitric oxide scavenging by increased superoxide production, is a hallmark of vascular disease states. However, molecular mechanisms regulating superoxide production in human blood vessels remain poorly defined. METHODS AND RESULTS: We compared endothelial function, vascular superoxide production, and the expression of NAD(P)H oxidase subunits in arteries and veins from patients undergoing coronary bypass surgery (n=86). Superoxide re...

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Authors: Guzik, T; Sadowski, J; Kapelak, B; Jopek, A; Rudzinski, P

• Publication status: Published
• Journal: Arteriosclerosis, thrombosis, and vascular biology
• Volume: 24
• Issue: 9
• Pages: 1614-1620
• Publication date: 2004-09-01
• DOI: 10.1161/01.atv.0000139011.94634.9d
• EISSN: 1524-4636
• ISSN: 1079-5642
• Language: English
• Keywords: Vasodilation; Acetylcholine; Nitric Oxide; Saphenous Vein; NADPH Oxidase; Phenanthridines; NADPH Dehydrogenase; Alkaloids; Endothelium, Vascular; Membrane Glycoproteins; Phosphoproteins; Coronary Disease; Superoxides; Female; Male; Aged; Benzophenanthridines; Protein Subunits; Humans; Protein Kinase C; Membrane Transport Proteins; Mammary Arteries