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GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model

Abstract:

Striatal dopamine (DA) is critical for action and learning. Recent data show that DA release is under tonic inhibition by striatal GABA. Ambient striatal GABA tone on striatal projection neurons can be determined by plasma membrane GABA uptake transporters (GATs) located on astrocytes and neurons. However, whether striatal GATs and astrocytes determine DA output are unknown. We reveal that DA release in mouse dorsolateral striatum, but not nucleus accumbens core, is governed by GAT-1 and GAT-...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Subgroup:
Physiology Anatomy & Genetics
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
11
Article number:
4958
Publication date:
2020-10-02
Acceptance date:
2020-08-13
DOI:
EISSN:
2041-1723
Pubs id:
1127569
Local pid:
pubs:1127569

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