Journal article
GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
- Abstract:
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Striatal dopamine (DA) is critical for action and learning. Recent data show that DA release is under tonic inhibition by striatal GABA. Ambient striatal GABA tone on striatal projection neurons can be determined by plasma membrane GABA uptake transporters (GATs) located on astrocytes and neurons. However, whether striatal GATs and astrocytes determine DA output are unknown. We reveal that DA release in mouse dorsolateral striatum, but not nucleus accumbens core, is governed by GAT-1 and GAT-...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 3.7MB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-020-18247-5
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Bibliographic Details
- Publisher:
- Springer Nature
- Journal:
- Nature Communications More from this journal
- Volume:
- 11
- Article number:
- 4958
- Publication date:
- 2020-10-02
- Acceptance date:
- 2020-08-13
- DOI:
- EISSN:
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2041-1723
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1127569
- Local pid:
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pubs:1127569
- Deposit date:
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2020-08-21
Terms of use
- Copyright holder:
- Roberts et al.
- Copyright date:
- 2020
- Rights statement:
- ©2020 The Author(s)
- Notes:
- Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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