Journal article
RASSF1A controls tissue stiffness and cancer stem‐like cells in lung adenocarcinoma
- Abstract:
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Lung cancer remains the leading cause of cancer‐related death due to poor treatment responses and resistance arising from tumour heterogeneity. Here, we show that adverse prognosis associated with epigenetic silencing of the tumour suppressor RASSF1A is due to increased deposition of extracellular matrix (ECM), tumour stiffness and metastatic dissemination in vitro and in vivo. We find that lung cancer cells with RASSF1A promoter methylation display constitutive nuclear YAP1 accumulation and ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 3.4MB)
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- Publisher copy:
- 10.15252/embj.2018100532
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Authors
Bibliographic Details
- Publisher:
- EMBO Press Publisher's website
- Journal:
- EMBO Journal Journal website
- Volume:
- 38
- Issue:
- 13
- Pages:
- 1-20
- Publication date:
- 2019-05-27
- Acceptance date:
- 2019-04-29
- DOI:
- EISSN:
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1460-2075
- ISSN:
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0261-4189
- Pmid:
-
31133556
- Source identifiers:
-
1003345
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1003345
- UUID:
-
uuid:86a2473b-f9cf-4d09-bbc9-555738e551b7
- Local pid:
- pubs:1003345
- Deposit date:
- 2019-06-30
Terms of use
- Copyright holder:
- Pankova et al
- Copyright date:
- 2019
- Notes:
- © 2019 The Authors. Published under the terms of the CC BY 4.0 license
- Licence:
- CC Attribution (CC BY)
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