- Abstract:
-
Lung cancer remains the leading cause of cancer‐related death due to poor treatment responses and resistance arising from tumour heterogeneity. Here, we show that adverse prognosis associated with epigenetic silencing of the tumour suppressor RASSF1A is due to increased deposition of extracellular matrix (ECM), tumour stiffness and metastatic dissemination in vitro and in vivo. We find that lung cancer cells with RASSF1A promoter methylation display constitutive nuclear YAP1 accumulation and ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 3.4MB)
-
- Publisher copy:
- 10.15252/embj.2018100532
-
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- Publisher:
- EMBO Press Publisher's website
- Journal:
- The EMBO Journal Journal website
- Volume:
- 38
- Issue:
- 13
- Pages:
- 1-20
- Publication date:
- 2019-05-27
- Acceptance date:
- 2019-04-29
- DOI:
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
- Pubs id:
-
pubs:1003345
- URN:
-
uri:86a2473b-f9cf-4d09-bbc9-555738e551b7
- UUID:
-
uuid:86a2473b-f9cf-4d09-bbc9-555738e551b7
- Local pid:
- pubs:1003345
- Language:
- English
- Keywords:
- Copyright holder:
- Pankova et al.
- Copyright date:
- 2019
- Notes:
- © 2019 The Authors. Published under the terms of the CC BY 4.0 license
Journal article
RASSF1A controls tissue stiffness and cancer stem‐like cells in lung adenocarcinoma
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