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Journal article

RASSF1A controls tissue stiffness and cancer stem‐like cells in lung adenocarcinoma

Abstract:

Lung cancer remains the leading cause of cancer‐related death due to poor treatment responses and resistance arising from tumour heterogeneity. Here, we show that adverse prognosis associated with epigenetic silencing of the tumour suppressor RASSF1A is due to increased deposition of extracellular matrix (ECM), tumour stiffness and metastatic dissemination in vitro and in vivo. We find that lung cancer cells with RASSF1A promoter methylation display constitutive nuclear YAP1 accumulation and ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.15252/embj.2018100532

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
ORCID:
0000-0003-3703-491X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
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Publisher:
EMBO Press Publisher's website
Journal:
The EMBO Journal Journal website
Volume:
38
Issue:
13
Pages:
1-20
Publication date:
2019-05-27
Acceptance date:
2019-04-29
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Pubs id:
pubs:1003345
URN:
uri:86a2473b-f9cf-4d09-bbc9-555738e551b7
UUID:
uuid:86a2473b-f9cf-4d09-bbc9-555738e551b7
Local pid:
pubs:1003345

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