Journal article icon

Journal article

Potassium channel regulation - Structural insights into the function of the nucleotide-binding domains of the human sulphonylurea receptor

Abstract:

The sulphonylurea receptor (SUR) is a member of the ATP-binding cassette (ABC) family of membrane proteins. It functions as the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which comprises SUR and Kir6.x proteins. Here, we review data demonstrating functional differences between the two nucleotide binding domains (NBDs) of SUR1. In addition, to explain the structural basis of these functional differences, we have constructed a molecular model of the NBD dimer of human SUR...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/sj.embor.7400003

Authors


Campbell, JD More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
EMBO REPORTS
Volume:
4
Issue:
11
Pages:
1038-1042
Publication date:
2003-11-05
DOI:
ISSN:
1469-221X
URN:
uuid:86a0d125-1168-432a-b939-f4e86c3d307e
Source identifiers:
100806
Local pid:
pubs:100806
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP