Journal article
Prion-like α-synuclein pathology in the brain of infants with Krabbe disease
- Abstract:
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Krabbe disease is an infantile neurodegenerative disorder resulting from pathogenic variants in the GALC gene that causes accumulation of the toxic sphingolipid psychosine. GALC variants are also associated with Lewy body diseases, an umbrella term for age-associated neurodegenerative diseases in which the protein α-synuclein aggregates into Lewy bodies. To explore whether α-synuclein in Krabbe disease has pathological similarities to that in Lewy body disease, we performed an observational p...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 611.4KB, Terms of use)
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- Publisher copy:
- 10.1093/brain/awac002
Authors
Contributors
+ International DLB Genetics Consortium
Role:
Contributor
+ Parkkinen, L
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Contributor
ORCID:
0000-0002-3392-8564
et al.
Bibliographic Details
- Publisher:
- Oxford University Press
- Journal:
- Brain More from this journal
- Volume:
- 145
- Issue:
- 4
- Pages:
- 1257-1263
- Publication date:
- 2022-01-06
- Acceptance date:
- 2021-12-10
- DOI:
- EISSN:
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1460-2156
- ISSN:
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0006-8950
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
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1343938
- Local pid:
-
pubs:1343938
- Deposit date:
-
2023-05-23
Terms of use
- Copyright holder:
- Hatton et al.
- Copyright date:
- 2022
- Rights statement:
- © The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
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