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Journal article

Design of a calcium-binding protein with desired structure in a cell adhesion molecule.

Abstract:

Ca2+, "a signal of life and death", controls numerous cellular processes through interactions with proteins. An effective approach to understanding the role of Ca2+ is the design of a Ca2+-binding protein with predicted structural and functional properties. To design de novo Ca2+-binding sites in proteins is challenging due to the high coordination numbers and the incorporation of charged ligand residues, in addition to Ca2+-induced conformational change. Here, we demonstrate the successful d...

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Publication status:
Published

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Publisher copy:
10.1021/ja0431307

Authors


Wilkins, AL More by this author
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Journal:
Journal of the American Chemical Society
Volume:
127
Issue:
7
Pages:
2085-2093
Publication date:
2005-02-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:86885a3f-75c4-485f-a26f-f3a7260a9d39
Source identifiers:
27883
Local pid:
pubs:27883

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