- Abstract:
-
Ca2+, "a signal of life and death", controls numerous cellular processes through interactions with proteins. An effective approach to understanding the role of Ca2+ is the design of a Ca2+-binding protein with predicted structural and functional properties. To design de novo Ca2+-binding sites in proteins is challenging due to the high coordination numbers and the incorporation of charged ligand residues, in addition to Ca2+-induced conformational change. Here, we demonstrate the successful d...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1021/ja0431307
-
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- Journal:
- Journal of the American Chemical Society
- Volume:
- 127
- Issue:
- 7
- Pages:
- 2085-2093
- Publication date:
- 2005-02-05
- DOI:
- EISSN:
-
1520-5126
- ISSN:
-
0002-7863
- URN:
-
uuid:86885a3f-75c4-485f-a26f-f3a7260a9d39
- Source identifiers:
-
27883
- Local pid:
- pubs:27883
- Copyright date:
- 2005
Journal article
Design of a calcium-binding protein with desired structure in a cell adhesion molecule.
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