Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study.

Journal article

Basic and clinical studies have shown that bone marrow cell therapy can improve cardiac function following infarction. In experimental animals, reported stem cell-mediated changes range from no measurable improvement to the complete restoration of function. In the clinic, however, the average improvement in left ventricular ejection fraction is around 2% to 3%. A possible explanation for the discrepancy between basic and clinical results is that few basic studies have used the magnetic resona...

Expand abstract

Authors: Carr, C; Stuckey, D; Tatton, L; Tyler, D; Hale, S

• Publication status: Published
• Journal: American journal of physiology. Heart and circulatory physiology
• Volume: 295
• Issue: 2
• Pages: H533-H542
• Publication date: 2008-08-01
• DOI: 10.1152/ajpheart.00094.2008
• EISSN: 1522-1539
• ISSN: 0363-6135
• Language: English
• Keywords: Rats, Wistar; Ferric Compounds; Carbocyanines; Time Factors; Myocardial Infarction; Myocardial Contraction; Ventricular Function, Left; Staining and Labeling; Cell Differentiation; Immunohistochemistry; Animals; Bone Marrow Transplantation; Cell Proliferation; Disease Models, Animal; Green Fluorescent Proteins; Stromal Cells; Magnetic Resonance Imaging, Cine; Rats; Cell Survival; Cells, Cultured; Flow Cytometry; Cell Movement; Myocardium; Bone Marrow Cells; Male; Stroke Volume; Fluorescent Dyes