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Nuclear proton dynamics and interactions with calcium signaling

Abstract:

Biochemical signals acting on the nucleus can regulate gene expression. Despite the inherent affinity of nucleic acids and nuclear proteins (e.g. transcription factors) for protons, little is known about the mechanisms that regulate nuclear pH (pHnuc), and how these could be exploited to control gene expression. Here, we show that pHnuc dynamics can be imaged using the DNA-binding dye Hoechst 33342. Nuclear pores allow the passage of medium-sized molecules (calcein), but protons must first bi...

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Publication status:
In press
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.yjmcc.2015.07.003

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Funding agency for:
Hulikova, A
Publisher:
Elsevier Publisher's website
Journal:
Journal of molecular and cellular cardiology Journal website
Volume:
In Press, Corrected Proof
Publication date:
2015-07-13
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
Source identifiers:
533821
Language:
English
Keywords:
Pubs id:
pubs:533821
UUID:
uuid:867f1305-fca7-4def-a797-bf5483cee379
Local pid:
pubs:533821
Deposit date:
2016-02-10

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