Journal article
Nuclear proton dynamics and interactions with calcium signaling
- Abstract:
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Biochemical signals acting on the nucleus can regulate gene expression. Despite the inherent affinity of nucleic acids and nuclear proteins (e.g. transcription factors) for protons, little is known about the mechanisms that regulate nuclear pH (pHnuc), and how these could be exploited to control gene expression. Here, we show that pHnuc dynamics can be imaged using the DNA-binding dye Hoechst 33342. Nuclear pores allow the passage of medium-sized molecules (calcein), but protons must first bi...
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- Publication status:
- In press
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.2MB)
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- Publisher copy:
- 10.1016/j.yjmcc.2015.07.003
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Journal of molecular and cellular cardiology Journal website
- Volume:
- In Press, Corrected Proof
- Publication date:
- 2015-07-13
- DOI:
- EISSN:
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1095-8584
- ISSN:
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0022-2828
- Source identifiers:
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533821
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:533821
- UUID:
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uuid:867f1305-fca7-4def-a797-bf5483cee379
- Local pid:
- pubs:533821
- Deposit date:
- 2016-02-10
Terms of use
- Copyright holder:
- Hulikova and Swietach
- Copyright date:
- 2015
- Notes:
- Open Access funded by British Heart Foundation. Under a Creative Commons license.
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