Journal article
Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle.
- Abstract:
-
Obesity is increasingly prevalent, strongly associated with nonalcoholic liver disease, and a risk factor for numerous cancers. Here, we describe the liver-related consequences of long-term diet-induced obesity. Mice were exposed to an extended obesity model comprising a diet high in trans-fats and fructose corn syrup concurrent with a sedentary lifestyle. Livers were assessed histologically using the nonalcoholic fatty liver disease (NAFLD) activity score (Kleiner system). Mice in the Americ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.ajpath.2014.01.034
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Authors
Bibliographic Details
- Publisher:
- Elsevier Inc.
- Journal:
- The American journal of pathology
- Volume:
- 184
- Issue:
- 5
- Pages:
- 1550-1561
- Publication date:
- 2014-05-05
- DOI:
- EISSN:
-
1525-2191
- ISSN:
-
0002-9440
- URN:
-
uuid:866adf48-fa41-4339-ae10-408782b04d36
- Source identifiers:
-
482054
- Local pid:
- pubs:482054
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2014
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