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Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle.

Abstract:

Obesity is increasingly prevalent, strongly associated with nonalcoholic liver disease, and a risk factor for numerous cancers. Here, we describe the liver-related consequences of long-term diet-induced obesity. Mice were exposed to an extended obesity model comprising a diet high in trans-fats and fructose corn syrup concurrent with a sedentary lifestyle. Livers were assessed histologically using the nonalcoholic fatty liver disease (NAFLD) activity score (Kleiner system). Mice in the Americ...

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Publication status:
Published

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Authors


Dowman, JK More by this author
Hopkins, LJ More by this author
Reynolds, GM More by this author
Nikolaou, N More by this author
Armstrong, MJ More by this author
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Publisher:
Elsevier Inc.
Journal:
The American journal of pathology
Volume:
184
Issue:
5
Pages:
1550-1561
Publication date:
2014-05-05
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:866adf48-fa41-4339-ae10-408782b04d36
Source identifiers:
482054
Local pid:
pubs:482054

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