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Gene expression profiling of human oocytes at different maturational stages and after in vitro maturation.

Abstract:

OBJECTIVE: The purpose of this study was to catalog genes expressed in human oocytes at germinal vesicle (GV) or metaphase II (MII) stage and to compare gene profiles between oocytes matured in vivo (in vivo-MII) and in vitro (IVM-MII). STUDY DESIGN: University-based research utilizing unfertilized oocytes analyzed for > 29,000 genes with RNA amplification and microarray. RESULTS: GV, in vivo-MII, and IVM-MII oocytes expressed 12,219, 9735, and 8510 genes, respectively. There was extensiv...

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Publication status:
Published

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Publisher copy:
10.1016/j.ajog.2007.12.030

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Patrizio, P More by this author
Journal:
American journal of obstetrics and gynecology
Volume:
198
Issue:
4
Pages:
455.e1-455.e9
Publication date:
2008-04-05
DOI:
EISSN:
1097-6868
ISSN:
0002-9378
URN:
uuid:865ed4e0-7dd0-4e9e-884a-1ca0ce08f9e6
Source identifiers:
248231
Local pid:
pubs:248231

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