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Determination of N-linked glycosylation in viral glycoproteins by negative ion mass spectrometry and ion mobility

Abstract:
Glycan analysis of virion-derived glycoproteins is challenging due to the difficulties in glycoprotein isolation and low sample abundance. Here, we describe how ion mobility mass spectrometry can be used to obtain spectra from virion samples. We also describe how negative ion fragmentation of glycans can be used to probe structural features of virion glycans.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/978-1-4939-2874-3_7

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Publisher:
Springer New York Publisher's website
Volume:
1331
Pages:
93-121
Series:
Methods in Molecular Biology
Host title:
Carbohydrate-Based Vaccines
Publication date:
2015-07-21
DOI:
EISSN:
1940-6029
ISSN:
1064-3745
Source identifiers:
531878
ISBN:
9781493928736
Language:
English
Keywords:
Pubs id:
pubs:531878
UUID:
uuid:865ecae2-81c2-4083-8ec5-b4a05a0db1e6
Local pid:
pubs:531878
Deposit date:
2016-04-22

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