Journal article
Mathematical modeling of a hypoxia-regulated enclitic virus delivered by tumor-associated macrophages
- Abstract:
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Tumour hypoxia has long presented a challenge for cancer therapy: Poor vascularisation in hypoxic regions hinders both the delivery of chemotherapeutic agents and the response to radiotherapy, and hypoxic cancer cells that survive treatment can trigger tumour regrowth after treatment has ended. Tumourassociated macrophages are attractive vehicles for drug delivery because they localise in hypoxic areas of the tumour. In this paper, we derive a mathematical model for the infiltration of an in ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.7MB)
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- Publisher copy:
- 10.1016/j.jtbi.2018.10.044
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Authors
Funding
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Boemo, M
Grant:
Life Sciences Interface Doctoral Training Centre
+ European Commission
More from this funder
Funding agency for:
Boemo, M
Grant:
Life Sciences Interface Doctoral Training Centre
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Boemo, M
Grant:
Life Sciences Interface Doctoral Training Centre
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Journal of Theoretical Biology Journal website
- Volume:
- 461
- Pages:
- 102-116
- Publication date:
- 2018-10-23
- Acceptance date:
- 2018-10-22
- DOI:
- EISSN:
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1095-8541
- ISSN:
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0022-5193
- Source identifiers:
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936135
Item Description
- Keywords:
- Pubs id:
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pubs:936135
- UUID:
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uuid:865a9aa1-98f5-446b-b902-503833021c19
- Local pid:
- pubs:936135
- Deposit date:
- 2018-11-02
Terms of use
- Copyright holder:
- Boemo and Byrne
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license.
- Licence:
- CC Attribution (CC BY)
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