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Structure and function of the human MHC class Ib molecules HLA-E, HLA-F and HLA-G.

Abstract:

The major histocompatibility (MHC) class Ib molecules HLA-E, HLA-F and HLA-G are relatively non-polymorphic compared to class Ia molecules. Both HLA-E and HLA-G bind peptides and are involved in natural killer (NK)-cell recognition, but the role of HLA-F is unclear. HLA-E binds specifically to the conserved leader sequence peptides from the class Ia MHC molecules and interacts on the cell surface with the CD94/NKG2 class of NK-cell receptors. The framework structure of HLA-E is similar to tha...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Role:
Author
Journal:
Immunological reviews
Volume:
163
Issue:
1
Pages:
129-138
Publication date:
1998-06-05
DOI:
EISSN:
1600-065X
ISSN:
0105-2896
URN:
uuid:8659e8da-02ab-46b7-bb35-c838b0c3563d
Source identifiers:
25024
Local pid:
pubs:25024

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