Journal article
Clinical trial protocol for TARDOX: a phase I study to investigate the feasibility of targeted release of lyso-thermosensitive liposomal doxorubicin (ThermoDox®) using focused ultrasound in patients with liver tumours.
- Abstract:
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Background
TARDOX is a Phase I single center study of ultrasound triggered targeted drug delivery in adult oncology patients with incurable liver tumours. This proof of concept study is designed to demonstrate the safety and feasibility of targeted drug release and enhanced delivery of doxorubicin from thermally sensitive liposomes (ThermoDox®) triggered by mild hyperthermia induced by focused ultrasound in liver tumours. A key feature of the study is the direct quantification of...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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(pdf, 1.4MB)
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- Publisher copy:
- 10.1186/s40349-017-0104-0
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Authors
Funding
Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- Journal of Therapeutic Ultrasound Journal website
- Volume:
- 5
- Issue:
- 1
- Pages:
- 28
- Publication date:
- 2017-11-05
- Acceptance date:
- 2017-09-28
- DOI:
- EISSN:
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2050-5736
- Pubs id:
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pubs:744771
- URN:
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uri:8655fec7-c511-4516-a810-493297f593a7
- UUID:
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uuid:8655fec7-c511-4516-a810-493297f593a7
- Local pid:
- pubs:744771
Item Description
Terms of use
- Copyright holder:
- Middleton et al
- Copyright date:
- 2017
- Notes:
- © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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