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Clinical trial protocol for TARDOX: a phase I study to investigate the feasibility of targeted release of lyso-thermosensitive liposomal doxorubicin (ThermoDox®) using focused ultrasound in patients with liver tumours.

Abstract:

Background

TARDOX is a Phase I single center study of ultrasound triggered targeted drug delivery in adult oncology patients with incurable liver tumours. This proof of concept study is designed to demonstrate the safety and feasibility of targeted drug release and enhanced delivery of doxorubicin from thermally sensitive liposomes (ThermoDox®) triggered by mild hyperthermia induced by focused ultrasound in liver tumours. A key feature of the study is the direct quantification of...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1186/s40349-017-0104-0

Authors


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Institution:
University of Oxford
Division:
Continuing Education
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
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Publisher:
BioMed Central Publisher's website
Journal:
Journal of Therapeutic Ultrasound Journal website
Volume:
5
Issue:
1
Pages:
28
Publication date:
2017-11-05
Acceptance date:
2017-09-28
DOI:
EISSN:
2050-5736
Pubs id:
pubs:744771
URN:
uri:8655fec7-c511-4516-a810-493297f593a7
UUID:
uuid:8655fec7-c511-4516-a810-493297f593a7
Local pid:
pubs:744771

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