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Journal article

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.

Abstract:

AIMS/HYPOTHESIS: Hepatic insulin resistance is thought to be a critical component in the pathogenesis of type 2 diabetes but the role of intrinsic insulin signalling pathways in the regulation of hepatic metabolism remains controversial. Global gene targeting in mice and in vitro studies have suggested that IRS2 mediates the physiological effects of insulin in the liver. Reduced hepatic production of IRS2 is found in many cases of insulin resistance. To investigate the role of IRS2 in regulat...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-005-0084-4

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Journal:
Diabetologia
Volume:
49
Issue:
3
Pages:
552-561
Publication date:
2006-03-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:8640133b-965f-48ce-8e15-829a6a90a8c4
Source identifiers:
386919
Local pid:
pubs:386919

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