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Ceftriaxone as effective as long-acting chloramphenicol in short-course treatment of meningococcal meningitis during epidemics: a randomised non-inferiority study.

Abstract:

BACKGROUND: In sub-Saharan Africa in the 1990s, more than 600,000 people had epidemic meningococcal meningitis, of whom 10% died. The current recommended treatment by WHO is short-course long-acting oily chloramphenicol. Continuation of the production of this drug is uncertain, so simple alternatives need to be found. We assessed whether the efficacy of single-dose treatment of ceftriaxone was non-inferior to that of oily chloramphenicol for epidemic meningococcal meningitis. METHODS: In 2003...

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Publication status:
Published

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Journal:
Lancet
Volume:
366
Issue:
9482
Pages:
308-313
Publication date:
2005-01-01
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:86336726-ade2-44f1-af88-8af481974241
Source identifiers:
68033
Local pid:
pubs:68033

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