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Journal article

Functional consequences of the interaction of Ni2+ with the osteoclast Ca2+ 'receptor'.

Abstract:

Ni2+ was used as an extracellular activator of the Ca2+ 'receptor' in order to study the regulation of osteoclast function in vitro. Application of different micromolar concentrations of Ni2+ to osteoclasts bathed in 1.25 mM [Ca2+] and 0.8 mM [Mg2+] caused a concentration-dependent elevation of cytosolic [Ca2+] measured in single cells using fura-2 fluorescence. Cytosolic [Ca2+] responses to 5 mM [Ni2+] showed a rapidly developing and use-dependent inactivation, unlike those induced by the ap...

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Journal:
Experimental physiology
Volume:
78
Issue:
4
Pages:
517-529
Publication date:
1993-07-01
EISSN:
1469-445X
ISSN:
0958-0670
Source identifiers:
475705
Language:
English
Keywords:
Pubs id:
pubs:475705
UUID:
uuid:86335638-f1c3-4976-a328-a07a517d7e59
Local pid:
pubs:475705
Deposit date:
2014-07-14

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