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Mitochondrial proteome analysis reveals altered expression of voltage dependent anion channels in pancreatic β-cells exposed to high glucose.

Abstract:

Chronic hyperglycemia leads to deterioration of insulin release from pancreatic β-cells as well as insulin action on peripheral tissues. However, the mechanism underlying β-cell dysfunction resulting from glucose toxicity has not been fully elucidated. The aim of the present study was to define a set of alterations in mitochondrial protein profiles of pancreatic β-cell line in response to glucotoxic condition using 2-DE and tandem mass spectrometry. INS1E cells were incubated in the presence ...

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Publication status:
Published

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Publisher copy:
10.4161/isl.2.5.12639

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Role:
Author
Journal:
Islets
Volume:
2
Issue:
5
Pages:
283-292
Publication date:
2010-01-01
DOI:
EISSN:
1938-2022
ISSN:
1938-2014
URN:
uuid:86311779-de1a-43f3-b7de-f9c37e33af59
Source identifiers:
90357
Local pid:
pubs:90357

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