- Abstract:
-
Chronic hyperglycemia leads to deterioration of insulin release from pancreatic β-cells as well as insulin action on peripheral tissues. However, the mechanism underlying β-cell dysfunction resulting from glucose toxicity has not been fully elucidated. The aim of the present study was to define a set of alterations in mitochondrial protein profiles of pancreatic β-cell line in response to glucotoxic condition using 2-DE and tandem mass spectrometry. INS1E cells were incubated in the presence ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.4161/isl.2.5.12639
-
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- Journal:
- Islets
- Volume:
- 2
- Issue:
- 5
- Pages:
- 283-292
- Publication date:
- 2010-01-01
- DOI:
- EISSN:
-
1938-2022
- ISSN:
-
1938-2014
- URN:
-
uuid:86311779-de1a-43f3-b7de-f9c37e33af59
- Source identifiers:
-
90357
- Local pid:
- pubs:90357
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Mitochondrial proteome analysis reveals altered expression of voltage dependent anion channels in pancreatic β-cells exposed to high glucose.
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