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Comparing different analysis methods for quantifying the MRI amide proton transfer (APT) effect in hyperacute stroke patients.

Abstract:

Amide proton transfer (APT) imaging is a pH mapping method based on the chemical exchange saturation transfer phenomenon that has potential for penumbra identification following stroke. The majority of the literature thus far has focused on generating pH-weighted contrast using magnetization transfer ratio asymmetry analysis instead of quantitative pH mapping. In this study, the widely used asymmetry analysis and a model-based analysis were both assessed on APT data collected from healthy sub...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/nbm.3147

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
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Qualcomm Inc More from this funder
National Institute for Health Research More from this funder
Publisher:
Wiley Publisher's website
Journal:
NMR in Biomedicine Journal website
Volume:
27
Issue:
9
Pages:
1019-1029
Publication date:
2014-06-05
Acceptance date:
2014-05-07
DOI:
EISSN:
1099-1492
ISSN:
0952-3480
URN:
uuid:8630b58f-4d15-4aeb-9185-dbcdb674f8af
Source identifiers:
469300
Local pid:
pubs:469300

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