Journal article
Striatal dopamine transporter function is facilitated by converging biology of α-synuclein and cholesterol
- Abstract:
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Striatal dopamine transporters (DAT) powerfully regulate dopamine signalling, and can contribute risk to degeneration in Parkinson’s disease (PD). DATs can interact with the neuronal protein α-synuclein, which is associated with the aetiology and molecular pathology of idiopathic and familial PD. Here, we tested whether DAT function in governing dopamine (DA) uptake and release is modified in a human α-synuclein-overexpressing (SNCA-OVX) transgenic mouse model of early PD. Using fast-scan cyc...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 2.6MB, Terms of use)
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- Publisher copy:
- 10.3389/fncel.2021.658244
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Bibliographic Details
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Cellular Neuroscience More from this journal
- Volume:
- 15
- Article number:
- 658244
- Publication date:
- 2021-04-15
- Acceptance date:
- 2021-03-22
- DOI:
- ISSN:
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1662-5102
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1168880
- Local pid:
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pubs:1168880
- Deposit date:
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2021-03-22
Terms of use
- Copyright holder:
- Threlfell et al.
- Copyright date:
- 2021
- Rights statement:
- ©2021 Threlfell, Mohammadi, Ryan, Connor-Robson, Platt, Anand, Serres, Sharp, Bengoa-Vergniory, Wade-Martins, Ewing, Cragg and Brimblecombe. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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