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Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system.

Abstract:

Phosphodiesterases are key enzymes in the cAMP signaling cascade. They convert cAMP in its inactive form 5'-AMP and critically regulate the intensity and the duration of cAMP-mediated signals. Multiple isoforms exist that possess different intracellular distributions, different affinities for cAMP, and different catalytic and regulatory properties. This complex repertoire of enzymes provides a multiplicity of ways to modulate cAMP levels, to integrate more signaling pathways, and to respond t...

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Publisher copy:
10.1152/ajpheart.00766.2011

Authors


Stangherlin, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
302
Issue:
2
Pages:
H379-H390
Publication date:
2012-01-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:862a4aef-580b-4e71-bd8b-15646012d54c
Source identifiers:
237680
Local pid:
pubs:237680

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