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Journal article

Long-term thermostabilization of live poxviral and adenoviral vaccine vectors at supraphysiological temperatures in carbohydrate glass.

Abstract:

Live recombinant viral vectors based on adenoviruses and poxviruses are among the most promising platforms for development of new vaccines against diseases such as malaria, tuberculosis, and HIV-AIDS. Vaccines based on live viruses must remain infectious to be effective, so therefore need continuous refrigeration to maintain stability and viability, a requirement that can be costly and difficult, especially in developing countries. The sugars sucrose and trehalose are commonly used as stabili...

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Publication status:
Published

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Journal:
Science translational medicine
Volume:
2
Issue:
19
Pages:
19ra12
Publication date:
2010-02-01
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
Source identifiers:
54783
Language:
English
Keywords:
Pubs id:
pubs:54783
UUID:
uuid:86277a7d-54df-4b7b-a433-a9cbe00a122e
Local pid:
pubs:54783
Deposit date:
2012-12-19

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