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Journal article

Two-pore channels form homo- and heterodimers.

Abstract:

Two-pore channels (TPCs) have been recently identified as NAADP-regulated Ca(2+) release channels, which are localized on the endolysosomal system. TPCs have a 12-transmembrane domain (TMD) structure and are evolutionary intermediates between the 24-TMD α-subunits of Na(+) or Ca(2+) channels and the transient receptor potential channel superfamily, which have six TMDs in a single subunit and form tetramers with 24 TMDs as active channels. Based on this relationship, it is predicted that TPCs ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.c111.289835

Authors


Rietdorf, K More by this author
Funnell, TM More by this author
Heinemann, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
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Journal:
The Journal of biological chemistry
Volume:
286
Issue:
43
Pages:
37058-37062
Publication date:
2011-10-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:8624bc40-4219-49f0-a550-1f152c980f87
Source identifiers:
175196
Local pid:
pubs:175196

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