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T cell recognition of hapten. Anatomy of T cell receptor binding of a H-2kd-associated photoreactive peptide derivative.

Abstract:

To elucidate the structural basis of T cell recognition of hapten-modified antigenic peptides, we studied the interaction of the T1 T cell antigen receptor (TCR) with its ligand, the H-2Kd-bound Plasmodium berghei circumsporozoite peptide 252-260 (SYIPSAEKI) containing photoreactive 4-azidobenzoic acid (ABA) on P. berghei circumsporozoite Lys259. The photoaffinity-labeled TCR residue(s) were mapped as Tyr48 and/or Tyr50 of complementary determining region 2beta (CDR2beta). Other TCR-ligand co...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.274.6.3622

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Role:
Author
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Journal:
The Journal of biological chemistry
Volume:
274
Issue:
6
Pages:
3622-3631
Publication date:
1999-02-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:8617bb9f-f72f-4150-93df-c84af15a8bea
Source identifiers:
17908
Local pid:
pubs:17908

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