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Cutting edge: back to "one-way" germinal centers.

Abstract:

The present status of germinal center (GC) research is revisited using in silico simulations based on recent lymphocyte motility data in mice. The generally adopted view of several rounds of somatic hypermutations and positive selection is analyzed with special emphasis on the spatial organization of the GC reaction. We claim that the development of dark zones is not necessary for successful GC reactions to develop. We find that a recirculation of positively selected centrocytes to the dark z...

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Publication status:
Published

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Authors


Meyer-Hermann, ME More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Institute
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
174
Issue:
5
Pages:
2489-2493
Publication date:
2005-03-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:85fc8680-142c-441f-be0f-dfff6e382af1
Source identifiers:
29430
Local pid:
pubs:29430

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