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Journal article

Identification of transcriptional regulators in the mouse immune system.

Abstract:

The differentiation of hematopoietic stem cells into cells of the immune system has been studied extensively in mammals, but the transcriptional circuitry that controls it is still only partially understood. Here, the Immunological Genome Project gene-expression profiles across mouse immune lineages allowed us to systematically analyze these circuits. To analyze this data set we developed Ontogenet, an algorithm for reconstructing lineage-specific regulation from gene-expression profiles acro...

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Publisher copy:
10.1038/ni.2587

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Journal:
Nature immunology
Volume:
14
Issue:
6
Pages:
633-643
Publication date:
2013-06-05
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
URN:
uuid:85efb74a-5deb-4746-8775-a92392adf262
Source identifiers:
426235
Local pid:
pubs:426235

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