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VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.

Abstract:

Vascular endothelial growth factor (VEGF) is the most endothelial cell-specific angiogenic factor characterised to date, and it is produced by a variety of cell types. In macrophages, VEGF has been shown to be upregulated by the inflammatory mediator lipopolysaccharide (LPS) and by engagement of CD40 by CD40 ligand (CD40L). Because LPS and CD40L activate nuclear factor-kappaB (NF-kappaB) in monocytes, we investigated in this study whether VEGF production in macrophages, when stimulated with e...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.00286

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, BHF Centre of Research Excellence
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Journal of cell science
Volume:
116
Issue:
Pt 4
Pages:
665-674
Publication date:
2003-02-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:85dd6cea-e786-499c-909d-64c41ba5333f
Source identifiers:
225431
Local pid:
pubs:225431

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