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Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

Abstract:

Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and approximately 2.2 million...

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Publication status:
Published

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Publisher copy:
10.1038/ng.120

Authors


Zeggini, E More by this author
Voight, BF More by this author
Marchini, JL More by this author
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Journal:
Nature genetics
Volume:
40
Issue:
5
Pages:
638-645
Publication date:
2008-05-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:85cb7672-4203-4a99-b3ba-55c4ab26e593
Source identifiers:
25219
Local pid:
pubs:25219

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