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Metabolic profiles of dystrophin and utrophin expression in mouse models of Duchenne muscular dystrophy.

Abstract:

Metabolic profiles from (1)H nuclear magnetic resonance spectroscopy have been used to describe both one and two protein systems in four mouse models related to Duchenne muscular dystrophy using the pattern recognition technique partial least squares. Robust statistical models were built for extracts and intact cardiac tissue, distinguishing mice according to expression of dystrophin. Using metabolic profiles of diaphragm, models were built describing dystrophin and utrophin, a dystrophin rel...

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Publication status:
Published

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Authors


Griffin, JL More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Journal:
FEBS letters
Volume:
530
Issue:
1-3
Pages:
109-116
Publication date:
2002-10-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:85c40935-3b36-4d6f-934c-a12fc0d025be
Source identifiers:
106694
Local pid:
pubs:106694

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