- Abstract:
-
BACKGROUND: An altered nitric oxide-redox balance has been implicated in the pathogenesis of atrial fibrillation (AF). Statins inhibit NOX2-NADPH oxidases and prevent postoperative AF but are less effective in AF secondary prevention; the mechanisms underlying these findings are poorly understood. METHODS AND RESULTS: By using goat models of pacing-induced AF or of atrial structural remodeling secondary to atrioventricular block and right atrial samples from 130 patients undergoing cardiac su...
Expand abstract - Publisher copy:
- 10.1161/CIRCULATIONAHA.111.029223
-
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- Journal:
- Circulation
- Volume:
- 124
- Issue:
- 10
- Pages:
- 1107-1117
- Publication date:
- 2011-09-06
- DOI:
- EISSN:
-
1524-4539
- ISSN:
-
0009-7322
- URN:
-
uuid:85a5596f-eaef-4a0f-a7a2-66c4ff753d40
- Source identifiers:
-
170134
- Local pid:
- pubs:170134
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins.
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