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Thesis

Characterisation of the innate immune sensor MDA5

Abstract:

Melanoma Differentiation-Associated gene 5 (MDA5) is a cytosolic RNA receptor. Its activation triggers the production of the antiviral cytokines type I and III Interferons (IFN). It is believed that MDA5 detects viral and/or cellular RNAs. The latter case may be relevant in the context of cancer treatment with DNA demethylating agents, and in autoinflammatory and autoimmune diseases. In all these settings, physiological MDA5 agonists have not been identified. To identify MDA5-stimula...

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Department:
MRC-WIMM
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Author

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Department:
MRC-WIMM
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Supervisor
Role:
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Funding agency for:
Antonio Gregorio Dias Junior
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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