Journal article icon

Journal article

A transcription co-factor integrates cell adhesion and motility with the p53 response.

Abstract:

Despite its obvious importance in tumorigenesis, little information is available on the mechanisms that integrate cell motility and adhesion with nuclear events. JMY is a transcription co-factor that regulates the p53 response. In addition, JMY contains a series of WH2 domains that facilitate in vitro actin nucleation. We show here that the ability of JMY to influence cell motility is dependent, in part, on its control of cadherin expression as well as the WH2 domains. In DNA damage condition...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1073/pnas.0906785106

Authors


Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
106
Issue:
47
Pages:
19872-19877
Publication date:
2009-11-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:8576ba36-5fd3-4afa-a50f-21d88b8511de
Source identifiers:
269025
Local pid:
pubs:269025

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP