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Olanzapine increases slow-wave sleep: evidence for blockade of central 5-HT(2C) receptors in vivo.

Abstract:

BACKGROUND: The study aimed to determine the effects of the atypical antipsychotic agent, olanzapine, on the polysomnogram in healthy subjects. We predicted that olanzapine, via serotonin(2C) (5-HT(2C)) receptor blockade, would increase slow-wave sleep (SWS). METHODS: We studied the effects of single evening doses of olanzapine (5 mg and 10 mg orally) on the polysomnogram of 9 healthy male volunteers, using a placebo-controlled, double-blind, cross-over design. RESULTS: Compared to placebo, t...

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Publication status:
Published

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Authors


Sharpley, AL More by this author
Vassallo, CM More by this author
Journal:
Biological psychiatry
Volume:
47
Issue:
5
Pages:
468-470
Publication date:
2000-03-05
DOI:
EISSN:
1873-2402
ISSN:
0006-3223
URN:
uuid:856f7bf7-7d72-4f8b-b3b4-af5a9a919553
Source identifiers:
185770
Local pid:
pubs:185770

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