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A longitudinal study of autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison’s disease)

Abstract:

Autoantibodies directed against the P450 side chain cleavage enzyme (P450scc) have been recently described in dogs affected with hypoadrenocorticism, consistent with an immune-mediated pathogenesis of this endocrinopathy. In human autoimmune Addison’s disease, autoantibodies may have a predictive value, being detectable before clinical signs developing, and have been shown to persist for a period of time after diagnosis. Furthermore, an autoantibody positive status post-diagnosis has been ass...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.vetimm.2018.05.013

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
ORCID:
0000-0002-5909-2160
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Publisher:
Elsevier Publisher's website
Journal:
Veterinary Immunology and Immunopathology Journal website
Volume:
202
Pages:
41-45
Publication date:
2018-05-26
Acceptance date:
2018-05-25
DOI:
ISSN:
0165-2427
Pubs id:
pubs:858733
URN:
uri:8564dfbd-6120-4bee-ad4a-75d00d1ceea2
UUID:
uuid:8564dfbd-6120-4bee-ad4a-75d00d1ceea2
Local pid:
pubs:858733

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