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Implications of inter-population linkage disequilibrium patterns on the approach to a disease association study in the human MHC class III.

Abstract:

There is presently much interest in utilizing patterns of linkage disequilibrium (LD) to further genetic association studies. This is particularly pertinent in the class III region of the human major histocompatibility complex (MHC), which has been extensively studied as a disease susceptibility locus in a number of ethnic groups. To date, however, few studies of LD in the MHC have considered non-Caucasian populations. With the advent of large-scale haplotyping of the human genome, the questi...

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Publication status:
Published

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Publisher copy:
10.1007/s00251-006-0118-1

Authors


Hanchard, N More by this author
Diakite, M More by this author
Keating, B More by this author
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Journal:
Immunogenetics
Volume:
58
Issue:
5-6
Pages:
465-470
Publication date:
2006-06-05
DOI:
EISSN:
1432-1211
ISSN:
0093-7711
URN:
uuid:85620f67-35ed-4c1d-b615-9329e34aff48
Source identifiers:
133635
Local pid:
pubs:133635

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