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Enzyme-linked immunosorbent assay for the diagnosis of melioidosis: better than we thought.

Abstract:
We used Bayesian latent-class models to generate receiver operating characteristic curves and to revise the cutoff values for an enzyme-linked immunosorbent assay that has been developed previously for melioidosis. The new cutoff was unbiased towards misclassification caused by an imperfect gold standard and resulted in an increase in both sensitivity (from 66.4% to 80.2%) and specificity (82.1% and 95.0%).
Publication status:
Published

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Publisher copy:
10.1093/cid/cir080

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Teerawattanasook, N More by this author
Piriyagitpaiboon, K More by this author
Thanwisai, A More by this author
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Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume:
52
Issue:
8
Pages:
1024-1028
Publication date:
2011-04-05
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
URN:
uuid:855c6b5f-73f8-4267-9ea5-8410cb125b36
Source identifiers:
133557
Local pid:
pubs:133557

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